Ocular Blood Flow Velocity in Newly  Diagnosed Primary Open Angle Glaucoma  Patients Using Colour Doppler Imaging  Technique: Glaucoma

Saliu A.A. ISHOLA; Adeola O. ONAKOYA; Olufisayo ARIBABA; Folasade B. AKINSOLA; Kareem O. Musa; Adetunji A. ADENEKAN; Funmilayo I. MAYAKI

Authors

Saliu A.A. ISHOLA Department of Ophthalmology, Federal Medical Centre, Abeokuta, Ogun State
Adeola O. ONAKOYA Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos
Olufisayo ARIBABA Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos
Folasade B. AKINSOLA Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos
Kareem O. Musa Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos
Adetunji A. ADENEKAN Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos
Funmilayo I. MAYAKI Department of Ophthalmology, Lagos University Teaching Hospital, Idi-Araba, Lagos

Abstract

Background: While aetiology of open angle glaucoma has not been fully understood, elevated IOP has been identified as significant and currently only treatable risk factor.1 Nevertheless, many patients develop glaucoma progression despite reduced IOP, whereas others do not develop glaucoma in the presence of elevated IOP.2 This implies that other factors3,4 are involved in open angle glaucoma (OAG) onset and progression, including compromised vascular health. Several studies, performed with various techniques including colour Doppler imaging (CDI), have established that glaucoma is linked with decreased ocular blood flow(OBF), especially OBF in posteriorpole of the eye.5-7The aim of the study is to compare ocular blood flow (OBF) in newly diagnosed primary open-angle glaucoma (POAG) patients, with normal controls, using colour Doppler imaging (CDI) technique at the Lagos University Teaching Hospital (LUTH), Idi-Araba, Lagos.

References

Huck A, Siesky B, Kim N, Muchnik M, Kanakamedala P, Amireskandari A and Abrams-Tobe A. Vascular consideration in glaucoma patients of African and European descent. Acta Ophthalmologica. 2014; 92:336-340.

Heijl A, Leske MC, and Bengtsson B. Reduction of intraocular pressure and glaucoma progressive results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002; 120(10):1268-1279.

Harris AL, Kageman L, Ehrlich R, Rospigliosi C, Moore D and Siesky B. Measuring and interpreting ocular blood flow and metabolism in glaucoma. Can J Ophthalmol. 2008; 43:328-336.

Wentz SM, Kim NJ, Wang J, Amireskandari A, Siesky B and Harris A. Novel therapies for open angle glaucoma. F1000 Prime Reports. 2014; 6: 102.

Kaiser HJ, Shoetzau A, Stumpig D and Flammer J. Blood flow velocities of the extraocular vessels in patients with hightension and normal-tension primary glaucoma. Am J Ophthalmol. 1997; 123(23): 320-327.

Harris A, Sergot RC, Spaeth GL, Katz JL, Shoemaker JA and Martin BJ. Colour Doppler analysis of ocular blood vessel velocity in normal-tension glaucoma. Am J Ophthalmol. 1994; 118(5): 642-649.

Sugiyama T, Araie M, Riva CE, Schemetterer L and Orgul S. Use Speckle flow-graphy in ocular blood flow research. Acta Ophthalmol. 2010; 88(7): 723-729.

Garhofer G, Fuchsjager G, Vass C, Pemp B and Hommer A, Schmetterer W. Retrobulbar blood flow velocities in open angle-glaucoma and their association with mean arterial blood pressure. Invest. Ophthalmol. 2010; 51(12): 6652-6657.