Prevalence of Myocilin Gene Mutation in Adult-Onset Primary Open Angle Glaucoma and Non-Glaucoma Subjects who are Indigenes of Rivers State

A. A. Onua; C. N. Pedro-Egbe; E. A. Awoyesuku; B. O. Agaviezor; B. Ordinioha

Authors

A. A. Onua Department of Ophthalmology, University of Port Harcourt, Nigeria
C. N. Pedro-Egbe Department of Ophthalmology, University of Port Harcourt, Nigeria
E. A. Awoyesuku Department of Ophthalmology, University of Port Harcourt, Nigeria
B. O. Agaviezor Department of Animal Sciences/Genetics, University of Port Harcourt, Nigeria
B. Ordinioha School of Public Health, University of Port Harcourt, Nigeria

Keywords:

Prevalence, Rivers State indigenes, Adult-onset primary open angle glaucoma, Myocilin gene mutation

Abstract

Glaucoma is the leading cause of irreversible blindness incapacitating over 80million people worldwide1-3. Several pathogenetic
mechanisms have been postulated to explain the optic nerve damage that occur in POAG among which genetic predisposition is prominent. Gene-Linkage-based studies have identified genes associated with POAG: Myocilin, Optineurin, WDR36, Tank-Binding Kinase (TBK1) and APbb2^4-10.

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