Two Novel Single Nucleotide Polymorphisms in Myocilin Gene among Patients with Adult- Onset Primary Open Angle Glaucoma Indigenes of Rivers State, Nigeria

Azubuike A. Onua; Brilliant O. Agaviezor; Chinyere N. Pedro-Egbe

Authors

Azubuike A. Onua Department of Ophthalmology, University of Port Harcourt, Port Harcourt, Nigeria
Brilliant O. Agaviezor Department of Animal Science & Genetics, University of Port Harcourt, Port Harcourt, Nigeria
Chinyere N. Pedro-Egbe Department of Ophthalmology, University of Port Harcourt, Port Harcourt, Nigeria

Keywords:

Rivers State, Adult-onset Primary Open Angle Glaucoma, Novel Single Nucleotide Polymorphisms, Myocilin gene mutation

Abstract

Background:

Glaucoma is a heterogenous optic neuropathy with characteristic visual field defects resulting from the gradual retinal ganglion cell death and the second commonest cause of blindness worldwide1-5. Several pathogenetic theories have been postulated but the genetic factor is gaining more acceptance. Gene-Linkage-based studies have identified myocilin gene mutation to be associated with open-angle glaucoma^6-10.

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