Conjunctival Microbial Flora and Antibiotic Sensitivity in Newborns at Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State

O. A. Ayeni; O. O. Onabolu; H. A. Ajibode; O. O. Osinupebi; O. T. Bodunde; T. O. Otulana; V. A. Ayeni; O. O. Idowu

Authors

O. A. Ayeni Ogun State Hospital, Ifo, Ogun State, Nigeria
O. O. Onabolu Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
H. A. Ajibode Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
O. O. Osinupebi Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
O. T. Bodunde Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
T. O. Otulana Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
V. A. Ayeni Babcock University, Ilishan-Remo, Ogun State, Nigeria
O. O. Idowu Genentech Inc, South San Francisco, CA 94080, USA.

Abstract

Background: Micro-organisms are closely associated with the eye, forming the microbial flora of the ocular surface at birth while the inner parts of the eye remain sterile.1 The eye is protected from invasion of these organisms by protective mechanisms on the ocular surface such as the continuous secretion of tear film containing bactericidal substances,1-5 but any breach in the ocular surface from immunosuppression and/or trauma may predispose the eye to extraocular and/or intraocular infections.6 Normal ocular flora
in babies is influenced by factors that differ in different individuals. 7-12 The study aimed to determine conjunctival microbial flora, organisms implicated in ophthalmia neonatorum, and antibiotic sensitivity in newborns at Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria.

Views | Downloads: 33 / 0

References

Todar K. Todar’s Online Textbook of Bacteriology, http://www. textbookofbacteriology.net/ (accessed 25 September 2017)

Akpek E, Gottsch J. Immune defense at the ocular surface. Eye 2003; 17: 949– 956.

Lawrenson JG, Murphy PJ, Esmaeelpour M. The neonatal tear film. Cont Lens Anterior Eye 2003; 26(4): 197–202

Etches PC, Leahy F, Harris D, Baum JD. Lysozyme in the tears of newborn babies. Arch Dis Child 1979; 54: 218–221

Ponder E, Kennedy W. On the act of blinking. Dep Physiol Edinburgh Univ 1927; 89–110

Dalal I, Roifman C. Immunity of the newborn. In: Stiehm ER (ed) UpToDate, Waltham, MA. (accessed 26 September 2017)

Tough SC, Siever JE, Benzies K, Leew S, Johnston DW. Maternal well-being and its association to risk of developmental problems in children at school entry. BMC Pediatr 2010; 10: 19.

Lee PW, Jun KA, Cho BC. A study of microbial flora of conjunctival sac in newborns. Korean J Ophthalmol 1989; 3: 38– 41. 60

Isenberg SJ, Apt L, Yoshimori R, McCarty JW, Alvarez SR. Source of the Conjunctival Bacterial Flora at Birth and Implications for Ophthalmia Neonatorum Prophylaxis. Am J Ophthalmol 1988; 106: 458–462

Capriotti JA, Pelletier JS, Shah M, Caivano DM, Rittaband DC. Normal ocular flora in healthy eyes from a rural population in Sierra Leone. Int Ophthalmol 2009; 29: 81– 84.

Eder M, Farina N, Sanabria RR, Ta CN, Koss M, Saodio M et al. Normal ocular flora in newborns delivered in two hospital centers in Argentina and Paraguay. Graefe’s Arch Clin Exp Ophthalmol 2005; 243: 1098–1107

Rao PN, Rao KN. Study of the normal conjunctival flora (bacterial and fungal) and its relations to external ocular infections. Indian J Ophthalmol 1972; 20: 164–170

Mundia D, Ilako D, Masinde M. Risk of developing neonatal conjunctivitis in newborns of mothers with prolonged labour. East African J Ophthalmol 2008; 14: 5–127.