Neuromyelitis Optica Involving the Area Postrema in a Nigerian Female: A Case Report
Abstract
Introduction: Neuromyelitis optica spectrum disorders (NMOSD) are a group of inflammatory diseases associated with demyelination of the central nervous system involving the optic nerves, brain and spinal cord.1 The clinical features, findings on neuroimaging, immunology, and histopathology are distinct.2 Literature on NMOSD in Africans is scarce.
Aim: This is to report a case of neuro-myelitis optica involving the area postrema in a Nigerian female.
References
Mealy MA, Wingerchuk DM, Greenberg BM, Levy M. Epidemiology of neuromyelitis optica in the United States: a multicenter analysis.
Arch Neurol. 2012; 69: 1176–1180.
Pandit L, Asgari N, Apiwattanakul M, Palace J, Paul F, Kleiter I et al. Demographic and clinical features of neuromyelitis optica: a
review. Mult Scler. 2015;21:845–853.
Dandu V, Siddamreddy S, Meegada S, Muppidi V, Challa T. Isolated Area Postrema Syndrome Presenting as Intractable Nausea
and Vomiting. Cureus. 2020; 12(2):e7058.
Kremer L, Mealy M, Jacob A, Nakashima I, Cabri P, Bigi S et al. Brainstem manifestations in neuromyelitis optica: a multicenter study of
patients. Mult Scler. 2014;20:843–847.
Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA. Neuromyelitis optica brain lesions
localized at sites of high aquaporin 4 expressions. Arch Neurol. 2006;63:964–968.
Wingerchuk D, Banwell B, Bennett J, Cabre P, Caroll W, Chitnis T et al. International consensus diagnostic criteria for
neuromyelitis optica spectrum disorders. Neurology. 2015;85:177–189.
Kunchok A, Malpas C, Nytrova P, Havrdova E, Alroughani R, Terzi M et. al. Clinical and therapeutic predictors of disease outcomes in
AQP4-IgG+ neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;38:1018-1068.