Correlation of Macula Ganglion Cell Complex Thickness and Central 10-2 Visual Field Changes of Patients with Primary Open Angle Glaucoma: A Multicenter Study in Lagos, Nigeria

AI Emenike; OT Aribaba; CA Okeke; RE Umeh; OM Onyekwelu; AO Onakoya

Authors

AI Emenike Guinness Eye Centre, Lagos University Teaching Hospital, LUTH, Lagos, Nigeria
OT Aribaba Guinness Eye Centre, Lagos University Teaching Hospital, LUTH, Lagos, Nigeria
CA Okeke Ancilla Catholic Eye Center, Lagos, Nigeria
RE Umeh College of Medicine and Surgery, University of Nigeria, Ituku Ozalla, Nigeria.
OM Onyekwelu Guinness Eye Centre, Lagos University Teaching Hospital, LUTH, Lagos, Nigeria
AO Onakoya Guinness Eye Centre, Lagos University Teaching Hospital, LUTH, Lagos, Nigeria

Abstract

The macula region bears the highest density of retinal ganglion cells (RGC).¹ Macula damage is seen early in glaucoma using the ganglion cell complex (mGCC or mGCL++) of the Optical Coherence Tomography (OCT).² Standard Automated Perimetry (SAP) is an integral tool in glaucoma diagnosis and management in our local clinics. On SAP, this macula region falls within 10 degrees from fixation. This area is better tested using the 10-2 visual field (VF) tests than the 24-2 VF test because the former tests 68 points while the latter tests only 4 points within this 10 degrees.³ Early structural macula defects detected by OCT may correspond to functional defects detected using the 10-2 test. The aim of this study is to investigate the correlation of structure to function in glaucoma evaluation, if any, in order to improve timely glaucoma diagnostic ability among African descents.

References

Curcio CA, Allen KA. Topography of ganglion cells in human retina. J Comp Neurol. 1990;300: 5-25.

Hood DC, Slobodnick A, Raza AS, et al. Early glaucoma involves both deep local, and shallow widespread, retinal nerve fiber damage of the

macular region. Invest Ophthalmol Vis Sci. 2014;55:632-649.

Grillo LM, Wang DL, Ramachandran R, et al. The 24-2 visual field test misses central macular damage confirmed by the 10-2 visual field test

and optical coherence tomography. Transl Vis Sci Technol. 2016;5:15-23.

Na JH, Kook MS, Lee Y, Baek S. Structure-function relationship of the macular visual field sensitivity and the ganglion cell complex thickness in glaucoma. Invest Ophthalmol Vis Sci. 2012;53:5044-5051.

Cho JW, Sung KR, Lee S, Yun SC, Kang SY, Choi J, et al. Relationship between visual field sensitivity and macular ganglion cell complex

thickness as measured by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:6401-6407.

Hood DC, Raza AS, de Moraes CG, et al. The nature of macular damage in glaucoma as revealed by averaging optical coherence

tomography data. Transl Vis Sci Technol. 2012;1:3-8.